Metabolomic Associations with Serum Bone Turnover Markers

Bone turnover markers.

Bones are constantly remodelled to cope with the body's calcium requirements and to repair microscopic damage. The entire skeleton is replaced every 10 years in adults, and around 10% of the skeleton is involved in bone remodelling at any one time.

Serum levels of bone turnover markers following total joint arthroplasty.

PURPOSE To evaluate changes in serum levels of bone turnover markers during the first year following a total hip or knee arthroplasty (THA or TKA, respectively). METHODS 34 women and 13 men (mean age, 68 years) with idiopathic hip or knee osteoarthritis underwent elective THA or TKA. The serum levels of (1) osteoprotegerin, (2) nuclear factor-kappa B ligand (RANKL), (3) osteocalcin, and (4) b...

Serum concentration of biochemical bone turnover markers in vegetarian children.

PURPOSE In general, most children on well-planed vegetarian diets can achieve normal growth and development. However, elimination of animal products from the diet decreases the intake of some essential nutrients, such as calcium and vitamin D, and may influence bone metabolism. This is especially important in childhood and adolescence, when growth and bone turnover are most intensive. The aim o...

New Biochemical Serum Markers of Bone Turnover in Renal Osteodystrophy

Renal osteodystrophy is a multifactorial disorder of bone remodelling that develops in patients with chronic renal failure. During the last few years numerous biochemical markers of bone turnover have been proposed for the non-invasive diagnosis of renal osteodystrophy. Several enzymes and matrix proteins produced by osteoblasts and osteoclasts, including collagen type I degradation products, h...

Serum Leptin and Bone Turnover Markers in Postmenopausal Osteoporosis